KPV Anti-Inflammatory Peptide Research
KPV tripeptide research — alpha-MSH(11-13) derived anti-inflammatory mechanisms, NF-kB pathway modulation, mucosal immunity, IBD research models, and antimicrobial activity studies.
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KPV (Lysine-Proline-Valine)
Also known as: KPV, Alpha-MSH(11-13), Lys-Pro-Val
KPV is the C-terminal tripeptide (amino acids 11-13) of alpha-melanocyte-stimulating hormone (alpha-MSH). Despite being the smallest anti-inflammatory fragment of alpha-MSH, KPV retains potent anti-inflammatory activity through a unique mechanism that does not require melanocortin receptor binding. This distinguishes it from full-length alpha-MSH and melanotan peptides, which act through MC1R-MC5R...
Quick Facts
Sequence: Lys-Pro-Val
MW: 342.43 g/mol
CAS: 67727-97-3
Store lyophilized powder at -20C. KPV is a very small tripeptide and is relatively stable. Reconstituted solution at 2-8...
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Read ArticleResearch Applications
Key research categories and applications studied in the scientific literature.
Immune Support
A tripeptide that serves as a potent anti-inflammatory, helps heal gut barrier dysfunction, and aids in reducing infection through NF-kB pathway modulation.
Insulin Sensitivity
KPV's anti-inflammatory mechanisms reduce gut inflammation which is increasingly linked to metabolic dysfunction and insulin resistance in preclinical research.
Recovery & Healing
By suppressing NF-kB nuclear translocation and reducing pro-inflammatory cytokines, KPV supports mucosal healing and tissue recovery in IBD and colitis models.
Frequently Asked Questions
Common questions about kpv research research, purity standards, and sourcing.
What is KPV?
KPV (Lysine-Proline-Valine) is a tripeptide fragment derived from alpha-melanocyte stimulating hormone (alpha-MSH), specifically positions 11-13. It retains the anti-inflammatory properties of alpha-MSH without melanogenic effects.
How does KPV reduce inflammation?
KPV inhibits NF-kB nuclear translocation, reducing the transcription of pro-inflammatory cytokines including TNF-alpha, IL-6, and IL-1beta. It enters cells and directly interacts with the inflammatory signaling cascade at the nuclear level.
What is KPV studied for?
KPV is primarily studied in inflammatory bowel disease (IBD) models, colitis research, mucosal immunity, and antimicrobial applications. It shows particular promise in gut inflammation models where it reduces inflammatory markers and promotes mucosal healing.
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